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Prescription: Murder
1968 · Film · 100 min
Directed by Richard Irving
In Columbo's first outing, a psychiatrist uses a patient he is having an affair with to help him kill his wife, but his perfect alibi may come apart at the hands of a seemingly befuddled LAPD lieutenant.
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Also, Columbo's Peugeot 403 Cabriolet shows up in each of the first-season episodes (according to imcdb.org the "Internet Movie Cars Database" that I just discovered the existence of):
• 1. "Murder by the Book" https://www.imcdb.org/vehicle_147439-Peugeot-403-Cabriolet-1960.html
• 2. "Death Lends a Hand" https://www.imcdb.org/vehicle_88435-Peugeot-403-Cabriolet-1960.html
• 3. "Dead Weight" https://www.imcdb.org/vehicle_66108-Peugeot-403-Cabriolet-1960.html
• 4. "Suitable for Framing" https://www.imcdb.org/vehicle_94005-Peugeot-403-Cabriolet-1960.html
• 5. "Lady in Waiting" https://www.imcdb.org/vehicle_71913-Peugeot-403-Cabriolet-1960.html
• 6. "Short Fuse" https://www.imcdb.org/vehicle_36906-Peugeot-403-Cabriolet-1960.html
• 7. "Blueprint for Murder" https://www.imcdb.org/vehicle_75558-Peugeot-403-Cabriolet-1960.html
But there were two TV movies (the second one made as a "pilot") before it became a TV series, and in the first one Columbo is briefly shown with a different car, a Chevrolet C-Series:
"Prescription: Murder" https://www.imcdb.org/vehicle_876671-Chevrolet-C-Series-1967.html
(He doesn't seem to complain about his car in either of them though, so by the time he's complained about it, the car has already been shown on screen, including multiple times in the first episode.)